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Article

TGF-beta-regulated collagen type I accumulation: role of Src-based signals.

American journal of physiology. Cell physiology - 1 Apr 2007

Mishra Rangnath, Zhu Ling, Eckert Richard L, Simonson Michael S

Abstract excerpt

Transforming growth factor-beta (TGF-beta) stimulates myofibroblast transdifferentiation, leading to type I collagen accumulation and fibrosis. We investigated the function of Src in TGF-beta-induced collagen I accumulation. In human mesangial cells, PTyr416 Src (activated Src) was 3.3-fold higher in TGF-beta-treated cells than in controls. Src activation by TGF-beta was blocked by rottlerin and by a dominant...

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Identifiers

PMID: 17135298
DOI: 10.1152/ajpcell.00370.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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