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Article

TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectin.

Biochimica et biophysica acta - 22 Mar 2005

Kim Hwang-Phill, Kim Tai-Young, Lee Mi-Sook, Jong Hyun-Soon, Kim Tae-You, Lee Jung Weon, Bang Yung-Jue

Abstract excerpt

Integrin-mediated cell adhesion transduces signals to regulate actin cytoskeleton and cell proliferation. While understanding how integrin signals cross-talk with the TGF-beta1 pathways, we observed lamellipodia formation and cyclin regulation in Hep3B cells, following TGF-beta1 treatment. To answer if integrin signaling via actin organization might regulate cell cycle progression after TGF-beta1 treatment, we...

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Share to CSK Tyrosine-Protein Kinase
Share to Cyclin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

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Source

Identifiers

PMID: 15777850
DOI: 10.1016/j.bbamcr.2004.09.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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