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Article

Tumor-matrix interaction induces phenotypic switching in liver cancer cells.

Hepatology international - 1 Jun 2022

Yuan Ray-Hwang, Hsu Chia-Lang, Jhuang Yu-Lin, Liu Yun-Ru, Hsieh Tsung-Han, Jeng Yung-Ming

Abstract excerpt

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is characterized by fibrous stroma and clinical behavior more aggressive than that of hepatocellular carcinoma (HCC). Scirrhous HCC is a subtype of HCC with fibrous stroma, frequently has partial cholangiocytic differentiation, and is more likely to have an aggressive behavior. This study explored the interaction of liver cancer cells with the extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35525880
DOI: 10.1007/s12072-022-10315-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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