Article
Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.
Hepatology (Baltimore, Md.) - 1 Jan 2000
Carloni V, Pinzani M, Giusti S, Romanelli R G, Parola M, Bellomo G, Failli P, Hamilton A D, Sebti S M, Laffi G, Gentilini P
Abstract excerpt
Focal adhesion kinase (FAK) is a widely expressed nonreceptor tyrosine kinase found in focal adhesions. FAK has been indicated as a point of convergence of other signaling pathways including platelet-derived growth factor (PDGF) receptors, and recently, FAK tyrosine phosphorylation has been shown to be stimulated by PDGF. In the present study we assessed the role of Ras as a possible intermediate protein...
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