Article
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
23 Sept 2004
Abstract excerpt
Activation of hepatic stellate cells (HSCs) and other resident mesenchymal cells into myofibroblasts expressing alpha smooth muscle actin (alphaSMA) and collagen I is a key event in liver fibrogenesis. However, the temporal expression profiles of alphaSMA and collagen I genes in these cells is unknown. To address this question, we studied alphaSMA and collagen alpha1(I) transcriptional patterns in primary...