Article
Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass.
Journal of human genetics - 1 Mar 2021
Feng Gui-Juan, Wei Xin-Tong, Zhang Hong, Yang Xiao-Lin, Shen Hui, Tian Qing, Deng Hong-Wen, Zhang Lei, Pei Yu-Fang
Abstract excerpt
Bone mineral density (BMD) and lean body mass (LBM) not only have a considerable heritability each, but also are genetically correlated. However, common genetic determinants shared by both traits are largely unknown. In the present study, we performed a bivariate genome-wide association study (GWAS) meta-analysis of hip BMD and trunk lean mass (TLM) in 11,335 subjects from 6 samples, and performed replication in...
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