Article
Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease.
International journal of molecular sciences - 20 May 2024
Reppe Sjur, Gundersen Sveinung, Sandve Geir K, Wang Yunpeng, Andreassen Ole A, Medina-Gomez Carolina, Rivadeneira Fernando, Utheim Tor P, Hovig Eivind, Gautvik Kaare M
Abstract excerpt
Epidemiological evidence suggests existing comorbidity between postmenopausal osteoporosis (OP) and cardiovascular disease (CVD), but identification of possible shared genes is lacking. The skeletal global transcriptomes were analyzed in trans-iliac bone biopsies (n = 84) from clinically well-characterized postmenopausal women (50 to 86 years) without clinical CVD using microchips and RNA sequencing. One thousand...
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