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Article

Altered cfDNA Fragmentation Profile in Hypomethylated Regions as Diagnostic Marker in Breast Cancer

2021-05-25

Abstract excerpt

<title>Abstract</title> <p><bold>Backgroud: </bold>Breast cancer, the most common malignancy in women, has been proved to have both altered plasma cell-free DNA (cfDNA) methylation and fragmentation profiles, nevertheless, simultaneously detecting both of them for breast cancer diagnosis has never been reported. Moreover, although fragmentation pattern of cfDNA is determined by nuclease digestion of chromatin, st...

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Identifiers and source

Literature Corpus work
213614bb-4e5d-5ef4-9e88-34cd1becf48a
DOI
10.21203/rs.3.rs-490423/v1
Open publication

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