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Article

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity.

Cell research - 1 Feb 2016

Greer Eric Lieberman, Becker Ben, Latza Christian, Antebi Adam, Shi Yang

Abstract excerpt

Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan...

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Identifiers

PMID: 26691751
DOI: 10.1038/cr.2015.148
PMCID: PMC4746603

Genes

SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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