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Article

SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011

Nottke Amanda C, Beese-Sims Sara E, Pantalena Luiz F, Reinke Valerie, Shi Yang, Colaiácovo Monica P

Abstract excerpt

Regulation of histone methylation levels has long been implicated in multiple cellular processes, many of which involve transcription. Here, however, we report a unique role for the Caenorhabditis elegans histone demethylase SPR-5 in meiotic DNA double-strand break repair (DSBR). SPR-5 shows enzymatic activity toward H3K4me2 both in vitro and in the nematode germline, and spr-5 mutants show several phenotypes...

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Source

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Identifiers

PMID: 21768382
DOI: 10.1073/pnas.1102298108
PMCID: PMC3150895

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair.PMID 21768382Read ↗

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