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Article

H3K4 demethylase activities repress proliferative and postmitotic aging.

Aging cell - 1 Apr 2014

Alvares Stacy M, Mayberry Gaea A, Joyner Ebony Y, Lakowski Bernard, Ahmed Shawn

Abstract excerpt

Homeostasis of postmitotic and proliferating cells is maintained by pathways that repress stress. We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes. In addition, RBR-2 and SPR-5 were required for germ cell immortality at...

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Identifiers

PMID: 24134677
DOI: 10.1111/acel.12166
PMCID: PMC4020274

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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