Article

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

2019-02-06

Abstract excerpt

Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity by a still not fully understood mechanism. We find that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase (STS), raises the pool of sulfated steroid hormones and increases longevity. This increased longevity requires factors involved in germline-mediated longevity (...

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Identifiers and source

Literature Corpus work: 92191a7b-4f12-5f22-92b5-5470cac603f8
DOI: 10.1101/541730

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