Article
The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice.
Neurobiology of aging - 1 Jan 2016
Cacciottolo Mafalda, Christensen Amy, Moser Alexandra, Liu Jiahui, Pike Christian J, Smith Conor, LaDu Mary Jo, Sullivan Patrick M, Morgan Todd E, Dolzhenko Egor, Charidimou Andreas, Wahlund Lars-Olof, Wiberg Maria Kristofferson, Shams Sara, Chiang Gloria Chia-Yi, Finch Caleb E
Abstract excerpt
The apolipoprotein APOE4 allele confers greater risk of Alzheimer's disease (AD) for women than men, in conjunction with greater clinical deficits per unit of AD neuropathology (plaques, tangles). Cerebral microbleeds, which contribute to cognitive dysfunctions during AD, also show APOE4 excess, but sex-APOE allele interactions are not described. We report that elderly men diagnosed for mild cognitive impairment...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.