Article
Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction.
Brain imaging and behavior - 1 Jun 2014
Ungar Leo, Altmann Andre, Greicius Michael D
Abstract excerpt
Alzheimer's disease (AD) is an increasingly prevalent, fatal neurodegenerative disease that has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression. The ε4 allele of the Apolipoprotein E gene (APOE4) is a potent genetic risk factor for sporadic and late-onset familial AD. While the link between APOE4 and AD is strong, many expected effects, like increasing the risk of...
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