Article
Mutation profile of KRAS and BRAF genes in patients with colorectal cancer: association with morphological and prognostic criteria.
Genetics and molecular research : GMR - 14 Dec 2015
Samara M, Kapatou K, Ioannou M, Kostopoulou Ε, Papamichali R, Papandreou C, Athanasiadis A, Koukoulis G
Abstract excerpt
KRAS and BRAF mutations are well-recognized molecular alterations during colorectal carcinogenesis, but there is little agreement on their effect on tumor characteristics. Therefore, we aimed to evaluate the distribution of the most common KRAS and BRAF mutations in Greek patients with colorectal cancer and their possible associations with clinical histopathological parameters. In this study, 322 and 188...
Topics
- Amino Acid Substitution
- Codon
- Colorectal Neoplasms
- DNA Mutational Analysis
- Exons
- Female
- Humans
- Male
- Mutation
- Neoplasm Grading
- Neoplasm Staging