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Article

KRAS mutations in colorectal cancer from Tunisia: relationships with clinicopathologic variables and data on TP53 mutations and microsatellite instability.

Molecular biology reports - 1 Nov 2013

Aissi Sana, Buisine Marie-Pierre, Zerimech Farid, Kourda Nadia, Moussa Amel, Manai Mohamed, Porchet Nicole

Abstract excerpt

Mutations in KRAS gene are among the critical transforming alterations occurring during CRC tumorigenesis. Here we screened 51 primary CRC tumors from Tunisia for mutations in KRAS (codons 12 and 13) using PCR-direct sequencing. Our aim was to analyze tumor mutation frequencies and spectra in Tunisian patients with CRC. KRAS status and mutation site/type were than correlated with familial and clinicopathologic...

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Identifiers

PMID: 24078161
DOI: 10.1007/s11033-013-2722-0

Genes

KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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