Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer.

The International journal of biological markers - 1 Jan 2000

Symvoulakis E K, Zaravinos A, Panutsopulos D, Zoras O, Papalambros E, Sigala F, Spandidos D A

Abstract excerpt

BACKGROUND: The RAS/RAF/MEK/MAP kinase pathway is essential to intracellular signaling transduction regulating cell proliferation, differentiation and death. We investigated the occurrence of exon 15 BRAF and KRAS codon 12 mutations among Greek patients with colorectal cancer. METHODS: Sixty-one samples from patients with sporadic colorectal adenocarcinomas were studied for exon 15 BRAF mutations. DNA from...

Topics

Aged
Codon
Colorectal Neoplasms
Conserved Sequence
DNA Mutational Analysis
Exons
Female
Greece
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 17393356
DOI: 10.1177/172460080702200102

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17393356-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer.PMID 17393356Read ↗

Mutation Analysis of KRAS and BRAF in Iranian Colorectal Cancer patients: A Novel Variant in Exon 15 of BRAF.Semantic proximity Read ↗

Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer.Semantic proximity Read ↗

Mutation profile of KRAS and BRAF genes in patients with colorectal cancer: association with morphological and prognostic criteria.Semantic proximity Read ↗

High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.Semantic proximity Read ↗

Common KRAS and NRAS gene mutations in sporadic colorectal cancer in Northeastern Iranian patients.Semantic proximity Read ↗

KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: a cohort study.Semantic proximity Read ↗

BRAF mutations in sporadic colorectal carcinoma from polish patients.Semantic proximity Read ↗

[BRAF gene mutation in wild-type KRAS patients with colorectal cancers].Semantic proximity Read ↗

BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients.Semantic proximity Read ↗

Frequency and application of the hot spot BRAF gene mutation (p.V600E) in the diagnostic strategy for Hereditary Nonpolyposis Colorectal Cancer.Semantic proximity Read ↗

Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.Semantic proximity Read ↗

BRAF and K-ras gene mutations in human pancreatic cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.