Article
MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development.
PloS one - 1 Jan 2015
Sandrock Inga, Ziętara Natalia, Łyszkiewicz Marcin, Oberdörfer Linda, Witzlau Katrin, Krueger Andreas, Prinz Immo
Abstract excerpt
Thymic development of αβ T lymphocytes into invariant natural killer (NK) T cells depends on their selection via agonistic lipid antigen presented by CD1d. If successful, newly selected NKT cells gain effector functions already in the thymus. Some γδ T cell subsets also acquire effector functions in the thymus. However, it is not clear whether agonistic TCR stimulation is involved in thymic γδ T cell selection...
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