Article
Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014
Bedel Romain, Berry Richard, Mallevaey Thierry, Matsuda Jennifer L, Zhang Jingjing, Godfrey Dale I, Rossjohn Jamie, Kappler John W, Marrack Philippa, Gapin Laurent
Abstract excerpt
The self-reactivity of their T-cell antigen receptor (TCR) is thought to contribute to the development of immune regulatory cells, such as invariant NK T cells (iNKT). In the mouse, iNKT cells express TCRs composed of a unique Vα14-Jα18 rearrangement and recognize lipid antigens presented by CD1d molecules. We created mice expressing a transgenic TCR-β chain that confers high affinity for self-lipid/CD1d...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.