Article
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology.
PLoS biology - 1 Jan 2013
Vahl J Christoph, Heger Klaus, Knies Nathalie, Hein Marco Y, Boon Louis, Yagita Hideo, Polic Bojan, Schmidt-Supprian Marc
Abstract excerpt
Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain allowing conditional Vα14i-TCR expression from within the endogenous Tcrα locus. We demonstrate that naïve T cells...
Topics
- Animals
- Cell Differentiation
- Cell Lineage
- Cytokines
- Gene Knock-In Techniques
- Homeostasis
- Immunity, Innate
- Inflammation
- Lymphocyte Activation
- Lymphocyte Count
- Mice