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Article

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015

Wen Xiangshu, Kim Seil, Xiong Ran, Li Michelle, Lawrenczyk Agnieszka, Huang Xue, Chen Si-Yi, Rao Ping, Besra Gurdyal S, Dellabona Paolo, Casorati Giulia, Porcelli Steven A, Akbari Omid, Exley Mark A, Yuan Weiming

Abstract excerpt

Invariant NKT (iNKT) cells are unconventional innate-like T cells demonstrating potent antitumor function in conventional mouse models. However, the iNKT cell ligands have had limited efficacy in human antitumor clinical trials, mostly due to the profound differences in the properties and compositions of iNKT cells between the two species, including the presence of a CD8(+) subset of iNKT cells only in humans. To...

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Share to Antigens, CD1d
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 26157173
DOI: 10.4049/jimmunol.1500574
PMCID: PMC4530047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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