Article
CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs.
Scientific reports - 15 Sept 2015
Wang Chao, Liu Xi, Li Zhengyuan, Chai Yijie, Jiang Yunfeng, Wang Qian, Ji Yewei, Zhu Zhongli, Wan Ying, Yuan Zhenglong, Chang Zhijie, Zhang Minghui
Abstract excerpt
CD1d-dependent NKT cells have been extensively studied; however, the function of CD8(+)NKT-like cells, which are CD1d-independent T cells with NK markers, remains unknown. Here, we report that CD1d-independent CD8(+)NKT-like cells, which express both T cell markers (TCRβ and CD3) and NK cell receptors (NK1.1, CD49b and NKG2D), are activated and significantly expanded in mice immunized with GFP-expressing...
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