Article
Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus.
PloS one - 1 Jan 2008
Dashtsoodol Nyambayar, Watarai Hiroshi, Sakata Sakura, Taniguchi Masaru
Abstract excerpt
BACKGROUND: It is well known that CD1d-restricted Valpha14 invariant natural killer T (NKT) cells are derived from cells in the CD4(+)CD8(+) double-positive (DP) population in the thymus. However, the developmental progression of NKT cells in the earlier stages remains unclear, and the possible existence of NKT cell presursors in the earlier stages than DP stage remains to be tested. PRINCIPAL FINDINGS: Here, we...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cells, Cultured
- Cytokines
- Gene Expression Profiling
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Natural Killer T-Cells
- Phenotype