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Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells

1 Jun 2009

Abstract excerpt

NKT cells comprise a separate T lineage expressing semi-invariant T cell receptors. Canonical invariant NKT (iNKT) cells specifically recognize lipid Ags presented by CD1d, a MHC class I-like molecule. iNKT cells function, in part, as initial responders to bacterial infection and play a role in immune surveillance and tumor rejection. The Wiskott-Aldrich Syndrome protein (WASp) serves as a crucial link between...

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PMID: 19494259
DOI: 10.4049/jimmunol.0804256

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Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT CellsPMID 19494259Read ↗

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Wiskott–Aldrich syndrome protein (WASP) and N-WASP are critical for T cell developmentSemantic proximity Read ↗

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