Article
The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014
Drennan Michael B, Govindarajan Srinath, De Wilde Katelijne, Schlenner Susan M, Ware Carl, Nedospasov Sergei, Rodewald Hans-Reimer, Elewaut Dirk
Abstract excerpt
The regulatory role of the thymic microenvironment during trafficking and differentiation of the invariant NKT (iNKT) cell lineage remains poorly understood. In this study, we show that fractalkine receptor expression marks emigrating subpopulations of the NKT1, NKT2, and NKT17 sublineages in the thymus and peripheral organs of naive mice. Moreover, NKT1 sublineage cells can be subdivided into two subsets, namely...
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