Article
Hematopoietic Antigen Presenting Cells Fine-Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells.
European journal of immunology - 1 Jul 2026
Wang Yi, Lam Trang T, Ochiai Sotaro, Larson Abbie R, Matthews Dean B, McWilliam Hamish E G, Kaisho Tsuneyasu, Lahoud Mireille H, Villadangos Jose A, Diehl Gretchen E, Ronchese Franca, Pellicci Daniel G, Chong Mark M W
Abstract excerpt
The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells, in the thymus is distinct from conventional T cells. Unconventional αβ T cells adopt a memory phenotype, acquire effector functions, and can reside in the thymus long-term. It is well-established that positive selection of these unconventional T cells from CD4+CD8+...
Topics
- Animals
- Mice
- Natural Killer T-Cells
- Dendritic Cells
- Mice, Inbred C57BL
- Thymus Gland
- Receptors, Antigen, T-Cell, alpha-beta
- Macrophages
- Mucosal-Associated Invariant T Cells