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Article

Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods.

Statistics in medicine - 20 May 2016

Burgess Stephen, Dudbridge Frank, Thompson Simon G

Abstract excerpt

Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining information on multiple uncorrelated instrumental variables (IVs) into a single causal estimate are as follows: (i) allele scores, in which individual-level data on the IVs are aggregated into a univariate score, which is used as a single IV, and (ii) a...

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Identifiers

PMID: 26661904
DOI: 10.1002/sim.6835
PMCID: PMC4832315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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