Article
Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables.
Statistics in medicine - 30 May 2010
Burgess Stephen, Thompson Simon G, Burgess S, Thompson S G, Andrews G, Samani N J, Hall A, Whincup P, Morris R, Lawlor D A, Davey Smith G, Timpson N, Ebrahim S, Ben-Shlomo Y, Davey Smith G, Timpson N, Brown M, Ricketts S, Sandhu M, Reiner A, Psaty B, Lange L, Cushman M, Hung J, Thompson P, Beilby J, Warrington N, Palmer L J, Nordestgaard B G, Tybjaerg-Hansen A, Zacho J, Wu C, Lowe G, Tzoulaki I, Kumari M, Sandhu M, Yamamoto J F, Chiodini B, Franzosi M, Hankey G J, Jamrozik K, Palmer L, Rimm E, Pai J, Psaty B, Heckbert S, Bis J, Anand S, Engert J, Collins R, Clarke R, Melander O, Berglund G, Ladenvall P, Johansson L, Jansson J-H, Hallmans G, Hingorani A, Humphries S, Rimm E, Manson J, Pai J, Watkins H, Clarke R, Hopewell J, Saleheen D, Frossard R, Danesh J, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman J C M, Kardys I, Ben-Shlomo Y, Davey Smith G, Timpson N, de Faire U, Bennet A, Sattar N, Ford I, Packard C, Kumari M, Manson J, Lawlor Debbie A, Davey Smith George, Anand S, Collins R, Casas J P, Danesh J, Davey Smith G, Franzosi M, Hingorani A, Lawlor D A, Manson J, Nordestgaard B G, Samani N J, Sandhu M, Smeeth L, Wensley F, Anand S, Bowden J, Burgess S, Casas J P, Di Angelantonio E, Engert J, Gao P, Shah T, Smeeth L, Thompson S G, Verzilli C, Walker M, Whittaker J, Hingorani A, Danesh J
Abstract excerpt
Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context o...
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