Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data.

Abstract excerpt

Over the last decade the availability of SNP-trait associations from genome-wide association studies has led to an array of methods for performing Mendelian randomization studies using only summary statistics. A common feature of these methods, besides their intuitive simplicity, is the ability to combine data from several sources, incorporate multiple variants and account for biases due to weak instruments and...

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