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Article

Use of allele scores as instrumental variables for Mendelian randomization.

International journal of epidemiology - 1 Aug 2013

Burgess Stephen, Thompson Simon G

Abstract excerpt

BACKGROUND: An allele score is a single variable summarizing multiple genetic variants associated with a risk factor. It is calculated as the total number of risk factor-increasing alleles for an individual (unweighted score), or the sum of weights for each allele corresponding to estimated genetic effect sizes (weighted score). An allele score can be used in a Mendelian randomization analysis to estimate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24062299
DOI: 10.1093/ije/dyt093
PMCID: PMC3780999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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