Article
Using multiple genetic variants as instrumental variables for modifiable risk factors.
Statistical methods in medical research - 1 Jun 2012
Palmer Tom M, Lawlor Debbie A, Harbord Roger M, Sheehan Nuala A, Tobias Jon H, Timpson Nicholas J, Davey Smith George, Sterne Jonathan A C
Abstract excerpt
Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can require large sample sizes. However, an increasing number of genetic variants have been found to be robustly associated...
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