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Article

Using multiple genetic variants as instrumental variables for modifiable risk factors.

Statistical methods in medical research - 1 Jun 2012

Palmer Tom M, Lawlor Debbie A, Harbord Roger M, Sheehan Nuala A, Tobias Jon H, Timpson Nicholas J, Davey Smith George, Sterne Jonathan A C

Abstract excerpt

Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can req...

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Identifiers

PMID: 21216802
DOI: 10.1177/0962280210394459
PMCID: PMC3917707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21216802-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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