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Article

A Modified Debiased Inverse-Variance Weighted Estimator in Two-Sample Summary-Data Mendelian Randomization.

Statistics in medicine - 20 Dec 2024

Su Youpeng, Xu Siqi, Ma Yilei, Yin Ping, Hao Xingjie, Zhou Jiyuan, Fung Wing Kam, Jiang Hongwei, Wang Peng

Abstract excerpt

Mendelian randomization uses genetic variants as instrumental variables to estimate the causal effect of exposure on outcome from observational data. A common challenge in Mendelian randomization is that many genetic variants are only modestly or even weakly associated with the exposure of interest, a setting known as many weak instruments. Conventional methods, such as the popular inverse-variance weighted (IVW)...

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PMID: 39453381
DOI: 10.1002/sim.10245

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