Article
Characterization of genomic variations in SNPs of PE_PGRS genes reveals deletions and insertions in extensively drug resistant (XDR) M. tuberculosis strains from Pakistan.
International journal of mycobacteriology - 1 Mar 2015
Kanji Akbar, Hasan Zahra, Ali Asho, McNerney Ruth, Mallard Kim, Coll Francesc, Hill-Cawthorne Grant, Nair Mridul, Clark Taane G, Zaver Ambreen, Jafri Sana, Hasan Rumina
Abstract excerpt
BACKGROUND: Mycobacterium tuberculosis (MTB) PE_PGRS genes belong to the PE multigene family. Although the function of PE_PGRS genes is unknown, it is hypothesized that the PE_PGRS genes may be associated with antigenic variability in MTB. MATERIAL AND METHODS: Whole genome sequencing analysis was performed on (n=37) extensively drug-resistant (XDR) MTB strains from Pakistan, which included Lineage 1 (East...
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