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Article

Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Camassa Serena, Palucci Ivana, Iantomasi Raffaella, Cubeddu Tiziana, Minerva Mariachiara, De Maio Flavio, Jouny Samuel, Petruccioli Elisa, Goletti Delia, Ria Francesco, Sali Michela, Sanguinetti Maurizio, Manganelli Riccardo, Rocca Stefano, Brodin Priscille, Delogu Giovanni

Abstract excerpt

PE_PGRS33 is a surface-exposed protein of Mycobacterium tuberculosis (Mtb) which exerts its role in macrophages entry and immunomodulation. In this study, we aimed to investigate the polymorphisms in the pe_pgrs33 gene of Mtb clinical isolates and evaluate their impact on protein functions. We sequenced pe_pgrs33 in a collection of 135 clinical strains, genotyped by 15-loci MIRU-VNTR and spoligotyping and...

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Identifiers

PMID: 28484686
DOI: 10.3389/fcimb.2017.00137
PMCID: PMC5399086

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