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Analysis of complete genomes of Mycobacterium tuberculosis sublineage 2.1 (Proto-Beijing) revealed the presence of three pe_pgrs3-pe_pgrs4-like genes.

Scientific reports - 28 Dec 2024

Davies-Bolorunduro Olabisi Flora, Jaemsai Bharkbhoom, Ruangchai Wuthiwat, Noppanamas Thanakron, Boonbangyang Manon, Bodharamik Thavin, Sawaengdee Waritta, Mahasirimongkol Surakameth, Palittapongarnpim Prasit

Abstract excerpt

Mycobacterium tuberculosis Complex (MTBC), the etiological agent of tuberculosis (TB), demonstrates considerable genotypic diversity with distinct geographic distributions and variable virulence profiles. The pe-ppe gene family is especially noteworthy for its extensive variability and roles in host immune response modulation and virulence enhancement. We sequenced an Mtb genotype L2.1 isolate from Chiangrai,...

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PMID: 39730410
DOI: 10.1038/s41598-024-79351-w
PMCID: PMC11680800

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