Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.

mBio - 14 Jan 2014

Copin Richard, Coscollá Mireia, Seiffert Salome N, Bothamley Graham, Sutherland Jayne, Mbayo Georgetta, Gagneux Sebastien, Ernst Joel D

Abstract excerpt

UNLABELLED: The Mycobacterium tuberculosis genome includes the large family of pe_pgrs genes, whose functions are unknown. Because of precedents in other pathogens in which gene families showing high sequence variation are involved in antigenic variation, a similar role has been proposed for the pe_pgrs genes. However, the impact of immune selection on pe_pgrs genes has not been examined. Here, we sequenced 27...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to Epitopes, T-Lymphocyte

Share to INDEL Mutation

Share to Mycobacterium tuberculosis

Share to Selection, Genetic

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 24425732
DOI: 10.1128/mBio.00960-13
PMCID: PMC3903279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.PMID 24425732Read ↗

Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human hostSemantic proximity Read ↗

Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages.Semantic proximity Read ↗

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.Semantic proximity Read ↗

PE_PGRS proteins ofMycobacterium tuberculosis: A specialized molecular task force at the forefront of host–pathogen interactionSemantic proximity Read ↗

Variation of the Mycobacterium tuberculosis PE_PGRS 33 gene among clinical isolates.Semantic proximity Read ↗

Characterization of genomic variations in SNPs of PE_PGRS genes reveals deletions and insertions in extensively drug resistant (XDR) M. tuberculosis strains from Pakistan.Semantic proximity Read ↗

Mycobacterium tuberculosis PE_PGRS16 and PE_PGRS26 genetic polymorphism among clinical isolates.Semantic proximity Read ↗

Analysis of complete genomes of Mycobacterium tuberculosis sublineage 2.1 (Proto-Beijing) revealed the presence of three pe_pgrs3-pe_pgrs4-like genes.Semantic proximity Read ↗

Evolution of smooth tubercle Bacilli PE and PE_PGRS genes: evidence for a prominent role of recombination and imprint of positive selection.Semantic proximity Read ↗

Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation.Semantic proximity Read ↗

The Bioinformatics Analysis of Comparative Genomics of Mycobacterium tuberculosis Complex (MTBC) Provides Insight into Dissimilarities between Intraspecific Groups Differing in Host Association, Virulence, and Epitope DiversitySemantic proximity Read ↗

Are the PE‐PGRS proteins of Mycobacterium tuberculosis variable surface antigens?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.