Article
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages.
BMC genomics - 29 Feb 2016
Phelan Jody E, Coll Francesc, Bergval Indra, Anthony Richard M, Warren Rob, Sampson Samantha L, Gey van Pittius Nicolaas C, Glynn Judith R, Crampin Amelia C, Alves Adriana, Bessa Theolis Barbosa, Campino Susana, Dheda Keertan, Grandjean Louis, Hasan Rumina, Hasan Zahra, Miranda Anabela, Moore David, Panaiotov Stefan, Perdigao Joao, Portugal Isabel, Sheen Patricia, de Oliveira Sousa Erivelton, Streicher Elizabeth M, van Helden Paul D, Viveiros Miguel, Hibberd Martin L, Pain Arnab, McNerney Ruth, Clark Taane G
Abstract excerpt
BACKGROUND: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important...
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