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Single nucleotide polymorphisms in efflux pumps genes in extensively drug resistant Mycobacterium tuberculosis isolates from Pakistan.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2017

Kanji Akbar, Hasan Rumina, Ali Asho, Zaver Ambreen, Zhang Ying, Imtiaz Kehkashan, Shi Wanliang, Clark Taane G, McNerney Ruth, Phelan Jody, Rao Shoaib, Shafiq Samreen, Hasan Zahra

Abstract excerpt

It is challenging to understand mechanisms of drug resistance in Mycobacterium tuberculosis (MTB) due to the large variability in resistance associated genes. Efflux pump genes contribute to drug resistance and thus add to this complexity. Efflux pump gene protein superfamilies have been characterized by genome analysis of drug resistant strains and through in vitro transcriptional studies. However, there is...

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PMID: 29050768
DOI: 10.1016/j.tube.2017.07.012

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