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Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan.

Scientific reports - 11 May 2022

Napier Gary, Khan Anwar Sheed, Jabbar Abdul, Khan Muhammad Tahir, Ali Sajid, Qasim Muhammad, Mohammad Noor, Hasan Rumina, Hasan Zahra, Campino Susana, Ahmad Sajjad, Khattak Baharullah, Waddell Simon J, Khan Taj Ali, Phelan Jody E, Clark Taane G

Abstract excerpt

Tuberculosis, caused by Mycobacterium tuberculosis, is a high-burden disease in Pakistan, with multi-drug (MDR) and extensive-drug (XDR) resistance, complicating infection control. Whole genome sequencing (WGS) of M. tuberculosis is being used to infer lineages (strain-types), drug resistance mutations, and transmission patterns-all informing infection control and clinical decision making. Here we analyse WGS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35545649
DOI: 10.1038/s41598-022-11795-4
PMCID: PMC9095715

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