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Article

Is less really more: Does a prefrontal efficiency genotype actually confer better performance when working memory becomes difficult?

Cortex; a journal devoted to the study of the nervous system and behavior - 1 Jan 2016

Ihne Jessica L, Gallagher Natalie M, Sullivan Marie, Callicott Joseph H, Green Adam E

Abstract excerpt

Perhaps the most widely studied effect to emerge from the combination of neuroimaging and human genetics is the association of the COMT-Val(108/158)Met polymorphism with prefrontal activity during working memory. COMT-Val is a putative risk factor in schizophrenia, which is characterized by disordered prefrontal function. Work in healthy populations has sought to characterize mechanisms by which the valine (Val)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26649915
DOI: 10.1016/j.cortex.2015.10.025
PMCID: PMC7028246

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Is less really more: Does a prefrontal efficiency genotype actually confer better performance when working memory becomes difficult?PMID 26649915Read ↗

Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.Semantic proximity Read ↗

Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.Semantic proximity Read ↗

Sex differences in verbal working memory performance emerge at very high loads of common neuroimaging tasks.Semantic proximity Read ↗

COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination.Semantic proximity Read ↗

Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

Lack of association between COMT and working memory in a population-based cohort of healthy young adults.Semantic proximity Read ↗

COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.Semantic proximity Read ↗

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.Semantic proximity Read ↗

COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.Semantic proximity Read ↗

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