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Article

COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.

Cerebral cortex (New York, N.Y. : 1991) - 1 Mar 2010

Dennis Nancy A, Need Anna C, LaBar Kevin S, Waters-Metenier Sheena, Cirulli Elizabeth T, Kragel James, Goldstein David B, Cabeza Roberto

Abstract excerpt

The relationship between cognition and a functional polymorphism in the catechol-O-methlytransferase (COMT) gene, val108/158met, is one of debate in the literature. Furthermore, based on the dopaminergic differences associated with the COMT val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. To investigate these issues the...

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Identifiers

PMID: 19641018
DOI: 10.1093/cercor/bhp132
PMCID: PMC2820704

Genes

COMT

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.PMID 19641018Read ↗

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Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype.Semantic proximity Read ↗

Lack of association between COMT and working memory in a population-based cohort of healthy young adults.Semantic proximity Read ↗

Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

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