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Article

COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination.

Behavioral and brain functions : BBF - 13 Sept 2010

Rosa Elise C, Dickinson Dwight, Apud José, Weinberger Daniel R, Elvevåg Brita

Abstract excerpt

BACKGROUND: Dopamine in prefrontal cortex (PFC) modulates core cognitive processes, notably working memory and executive control. Dopamine regulating genes and polymorphisms affecting PFC--including Catechol-O-Methyltransferase (COMT) Val158Met--are crucial to understanding the molecular genetics of cognitive function and dysfunction. A mechanistic account of the COMT Val158Met effect associates the Met allele...

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Source

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Identifiers

PMID: 20836853
DOI: 10.1186/1744-9081-6-53
PMCID: PMC2945991

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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