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Article

Synthesis and Structure-Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors.

ACS chemical neuroscience - 17 Feb 2016

Singh Anamika, Kast Johannes, Dirain Marvin L S, Huang Huisuo, Haskell-Luevano Carrie

Abstract excerpt

The melanocortin system is involved in the regulation of several complex physiological functions. In particular, the melanocortin-3 and -4 receptors (MC3R/MC4R) have been demonstrated to regulate body weight, energy homeostasis, and feeding behavior. Synthetic and endogenous melanocortin agonists have been shown to be anorexigenic in rodent models. Herein, we report synthesis and structure-activity relationship...

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Identifiers

PMID: 26645732
DOI: 10.1021/acschemneuro.5b00273
PMCID: PMC5726298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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