Article

Development of a novel peripherally acting alpha2A-adrenergic receptor antagonist for anti-diabetic

2024-12-23

Abstract excerpt

<h4>Summary</h4> Yohimbine, a potent alpha2A-adrenergic receptor (α 2A AR) antagonist, was found therapeutic potential for type 2 diabetes through improving insulin release. However, the adverse side effects mediated by its actions in the brain hampered its use. Here, based on molecular docking analysis and structural modification, we have developed a novel peripherally acting yohimbine derivative (CDS479-2). Cr...

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Literature Corpus work: 24dc8fb2-eb0b-5c92-9a07-508195bb42bc
DOI: 10.1101/2024.12.17.628818

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