Article

Development of the novel amylin receptor activators with nanomolar potency by peptide mutagenesis

2024-08-01

Abstract excerpt

Amylin peptide hormone activates amylin receptors in brains and controls blood glucose and appetite. An amylin receptor activator pramlintide was developed for diabetes treatment. Currently, the amylin receptor activator with once-weekly injection has been tested for body weight reduction to treat obesity. Human amylin peptide was reported to form aggregates, while rat amylin has been shown soluble in aqueous solu...

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Literature Corpus work: 5ec4ef8e-f815-5d40-91c1-ae4998bf725e
DOI: 10.1101/2024.07.31.606116

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