Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor.

doi:10.1021/bi051316s

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Article

Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor.

Biochemistry - 8 Nov 2005

Fleck Beth A, Chen Chen, Yang Weidong, Huntley Rajesh, Markison Stacy, Nickolls Sarah A, Foster Alan C, Hoare Sam R J

Abstract excerpt

The melanocortin-4 (MC4) receptor is a potential therapeutic target for obesity and cachexia, for which nonpeptide agonists and antagonists are being developed, respectively. The aim of this study was to identify molecular interactions between the MC4 receptor and nonpeptide ligands, and to compare the mechanism of binding between agonist and antagonist ligands. Nonpeptide ligand interaction was affected by...

Topics

Amino Acid Sequence
Binding Sites
Cell Line
Cyclic AMP
Humans
Ligands
Models, Molecular
Molecular Sequence Data
Molecular Structure
Mutation
Protein Binding
Protein Structure, Secondary
Protein Structure, Tertiary
Receptor, Melanocortin, Type 4
alpha-MSH

Source

Open in PubMed

Identifiers

PMID: 16262250
DOI: 10.1021/bi051316s

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