Article

Development of a novel peripherally acting alpha2A-adrenergic receptor antagonist for anti-diabetic

2025-03-04

Abstract excerpt

<title>Abstract</title> <p>Yohimbine, a potent alpha2A-adrenergic receptor (α2AAR) antagonist, was found to carry therapeutic potential for type 2 diabetes through improving insulin release. However, adverse side effects mediated by its actions in the brain hampered its use. Here, we have developed a novel peripherally acting α2AAR antagonist, CDS479-2, based on molecular docking analysis and modification of yohi...

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Literature Corpus work: d1b5a06e-a755-537e-8d54-c5aaaf4bb86a
DOI: 10.21203/rs.3.rs-5741207/v1

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