Article

De novo designed cyclic MC4R peptide agonist reduces food intake in mice

2026-05-21

Abstract excerpt

Deep learning-based structure prediction enables the design of peptide ligands without relying on naturally occurring scaffolds. However, most computationally generated peptides are not advanced beyond initial activity measurements, leaving the path to drug-like optimization and in vivo validation underexplored. Here we establish an end-to-end workflow for de novo peptide agonist discovery and maturation using the...

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Identifiers and source

Literature Corpus work: be85420e-556e-5ab8-86f7-17fca1f54efb
DOI: 10.64898/2026.05.19.721857

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