Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).

doi:10.1021/jm500064t

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Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).

Journal of medicinal chemistry - 12 Jun 2014

Haslach Erica M, Huang Huisuo, Dirain Marvin, Debevec Ginamarie, Geer Phaedra, Santos Radleigh G, Giulianotti Marc A, Pinilla Clemencia, Appel Jon R, Doering Skye R, Walters Michael A, Houghten Richard A, Haskell-Luevano Carrie

Abstract excerpt

Human obesity has been linked to genetic factors and single nucleotide polymorphisms (SNPs). Melanocortin-4 receptor (MC4R) SNPs have been associated with up to 6% frequency in morbidly obese children and adults. A potential therapy for individuals possessing such genetic modifications is the identification of molecules that can restore proper receptor signaling and function. These compounds could serve as...

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PMID: 24517312
DOI: 10.1021/jm500064t
PMCID: PMC4324447

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Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).PMID 24517312Read ↗

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