Article

Morphine-induced hyperalgesia impacts small extracellular vesicle miRNA composition and function

2024-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Morphine and other synthetic opioids are widely prescribed to treat pain. Prolonged morphine exposure can paradoxically enhance pain sensitivity in humans and nociceptive behavior in rodents. To better understand the molecular mechanisms underlying opioid-induced hyperalgesia, we investigated changes in miRNA composition of small extracellular vesicles (sEVs) from the serum of mice after a morph...

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Literature Corpus work: 51d7c524-a1c9-5ee2-96d1-bf228076dc84
DOI: 10.1101/2024.10.17.617815

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